DEVELOPMENT AND EVALUATION OF MICROEMULSION FORMULATIONS OF BIFONAZOLE

Aim and objective: The purpose of this study was to develop microemulsion formulations for topical delivery bifonazole with an objective increase the solubility drug. Methods: Total 5 were developed using water titration method. Capmul Pg-12 (oil), Tween-80: (surfactant) Propylene glycol (co-surfactant) used in different ratio based on emulsification efficiency. Prepared evaluated parameters like transmittance (%), pH, refractive index, viscosity, drug content, solubility, in-vitro release Franz diffusion cell. Ternary phase diagram prepared oil (Capmul Pg-12), surfactant (Tween 80), co-surfactant (Propylene glycol) Results: % transmission found be range 98.47±0.09 99.2±0.08%, pH value 3.34±0.08 4.02±0.09, index 1.3418±0.016 1.3818±0.004, content 98.47± 0.08 99.62±0.02 %, viscosity 65.23±2.1 71.56±5.77%. It seen that after 4 hours diffusion, released from formulation ME5 faster more than other ratios i.e., 91.2±0.06%. observed governed by process. Conclusion: On basis evaluation batch best. Present concludes successful Bifonazole means Peer Review History: Received: March 2023; Revised: 26 April; Accepted: 20 June 2023, Available online: 15 July 2023 Academic Editor: Dr. Marwa A. Fayed, University Sadat City, Egypt, [email protected] Received file: Reviewer's Comments: Average review marks at initial stage: 5.5/10 publication 7.0/10 Reviewers: Rola Jadallah, Arab American University, Palestine, [email protected] Taiwo O Elufioye, Ibadan, Nigeria, [email protected]